Which genes besides PAX6 are implicated in anterior segment dysgenesis (e.g., FOXC1, PITX2)?

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Multiple Choice

Which genes besides PAX6 are implicated in anterior segment dysgenesis (e.g., FOXC1, PITX2)?

Explanation:
An important part of anterior segment development involves transcription factors like FOXC1 and PITX2. Mutations in either gene can disrupt neural crest–derived tissues that form the iris, cornea, and drainage angle, leading to anterior segment dysgenesis manifestations such as Axenfeld-Rieger spectrum. Because both FOXC1 and PITX2 are known contributors to this condition, the option that includes both genes is correct. Selecting only one or none would miss key genetic contributors seen in these disorders.

An important part of anterior segment development involves transcription factors like FOXC1 and PITX2. Mutations in either gene can disrupt neural crest–derived tissues that form the iris, cornea, and drainage angle, leading to anterior segment dysgenesis manifestations such as Axenfeld-Rieger spectrum. Because both FOXC1 and PITX2 are known contributors to this condition, the option that includes both genes is correct. Selecting only one or none would miss key genetic contributors seen in these disorders.

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